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- Title
Activity-dependent Extrinsic Regulation of Adult Olfactory Bulb and Hippocampal Neurogenesis.
- Authors
Ma, Dengke K.; Kim, Woon Ryoung; Ming, Guo‐li; Song, Hongjun
- Abstract
The adult mammalian brain continuously generates new neurons in the olfactory bulb and hippocampus throughout life. Adult neurogenesis, a highly dynamic process, has been shown to be exquisitely modulated by neuronal circuit activity at different stages, from proliferation of adult neural progenitors, to differentiation, maturation, integration, and survival of newborn neurons in the adult brain. Strategic activity-dependent addition of new neurons into the existing neuronal circuitry represents a prominent form of structural plasticity and may contribute to specific brain functions, such as learning, memory, and mood modulation. Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities.
- Subjects
OLFACTORY receptors; DEVELOPMENTAL neurobiology; HIPPOCAMPUS (Brain); MAMMALS; NEURONS
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1170, p664
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2009.04373.x