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- Title
Ethanol-Induced Decrease of the Expression of Glucose Transport Protein (Glut3) in the Central Nervous System as a Predisposing Condition to Apoptosis: The Effect of Age.
- Authors
FATTORETTI, P; BERTONI‐FREDDARI, C; CASOLI, T; STEFANO, G; GIORGETTI, G; SOLAZZI, M
- Abstract
We measured the effect of chronic ethanol administration on the expression of Glut3 in the cerebellum and hippocampus of adult and old rats. Glut3 expression significantly decreased in aging, in ethanol-treated rats vs. age-matched controls, and in adult- vs. old ethanol-treated rats. These findings lend consistent support to the hypothesis that disturbances of glucose metabolism due to ethanol may constitute an unfavorable condition predisposing to neuronal death.
- Subjects
APOPTOSIS; GLUCOSE; LABORATORY rats; MONOSACCHARIDES; METABOLISM; AGING; PHYSIOLOGY; CELL death; LABORATORY animals
- Publication
Annals of the New York Academy of Sciences, 2004, Vol 1010, Issue 1, p500
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1299.092