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- Title
Application of Privileged Molecular Framework of 7-Fluoro-1,4-benzodiazepin-2-one-5-methylcarboxylate to the Synthesis of Its 1- and 5-Disubstituted Analogs of Medicinal Interest.
- Authors
Devi, Pragati; Gupta, Aarti; Kishore, Dharma
- Abstract
Synthetic potential of the privileged molecular framework of 7-fluoro-1,4-benzodiazepin-2-one containing a methyl carboxylate substituent at its 5-position was exploited to develop efficient protocols to the synthesis of several novel 5-(1′,3′,4′)oxadiazole ring incorporated analogs of medicinal interest, appended with the Mannich's base motifs at the nitrogen atom in its seven-membered ring.
- Subjects
BENZENE compound synthesis; OXADIAZOLES; MOLECULAR structure; CARBOXYLATES; CHEMICAL synthesis
- Publication
Journal of Heterocyclic Chemistry, 2014, Vol 51, Issue 4, p991
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1621