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- Title
Oxygen‐enhanced functional lung imaging using a contemporary 0.55 T MRI system.
- Authors
Bhattacharya, Ipshita; Ramasawmy, Rajiv; Javed, Ahsan; Chen, Marcus Y.; Benkert, Thomas; Majeed, Waqas; Lederman, Robert J.; Moss, Joel; Balaban, Robert S.; Campbell‐Washburn, Adrienne E.
- Abstract
The purpose of this study was to evaluate oxygen‐enhanced pulmonary imaging at 0.55 T with 3D stack‐of‐spirals ultrashort‐TE (UTE) acquisition. Oxygen‐enhanced pulmonary MRI offers the measurement of regional lung ventilation and perfusion using inhaled oxygen as a contrast agent. Low‐field MRI systems equipped with contemporary hardware can provide high‐quality structural lung imaging by virtue of the prolonged T2*. Fortuitously, the T1 relaxivity of oxygen increases at lower field strengths, which is expected to improve the sensitivity of oxygen‐enhanced lung MRI. We implemented a breath‐held T1‐weighted 3D stack‐of‐spirals UTE acquisition with a 7 ms spiral‐out readout. Measurement repeatability was assessed using five repetitions of oxygen‐enhanced lung imaging in healthy volunteers (n = 7). The signal intensity at both normoxia and hyperoxia was strongly dependent on lung tissue density modulated by breath‐hold volume during the five repetitions. A voxel‐wise correction for lung tissue density improved the repeatability of percent signal enhancement maps (coefficient of variation = 34 ± 16%). Percent signal enhancement maps were compared in 15 healthy volunteers and 10 patients with lymphangioleiomyomatosis (LAM), a rare cystic disease known to reduce pulmonary function. We measured a mean percent signal enhancement of 9.0 ± 3.5% at 0.55 T in healthy volunteers, and reduced signal enhancement in patients with LAM (5.4 ± 4.8%, p = 0.02). The heterogeneity, estimated by the percent of lung volume exhibiting low enhancement, was significantly increased in patients with LAM compared with healthy volunteers (11.1 ± 6.0% versus 30.5 ± 13.1%, p = 0.01), illustrating the capability to measure regional functional deficits.
- Subjects
CONTRAST media; MAGNETIC resonance imaging; LUNGS; LUNG volume; RARE diseases
- Publication
NMR in Biomedicine, 2021, Vol 34, Issue 8, p1
- ISSN
0952-3480
- Publication type
Article
- DOI
10.1002/nbm.4562