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- Title
Robust universal nonrigid motion correction framework for first-pass cardiac MR perfusion imaging.
- Authors
Benovoy, Mitchel; Jacobs, Matthew; Cheriet, Farida; Dahdah, Nagib; Arai, Andrew E.; Hsu, Li‐Yueh; Hsu, Li-Yueh
- Abstract
<bold>Purpose: </bold>To present and assess an automatic nonrigid image registration framework that compensates motion in cardiac magnetic resonance imaging (MRI) perfusion series and auxiliary images acquired under a wide range of conditions to facilitate myocardial perfusion quantification.<bold>Materials and Methods: </bold>Our framework combines discrete feature matching for large displacement estimation with a dense variational optical flow formulation in a multithreaded architecture. This framework was evaluated on 291 clinical subjects to register 1.5T and 3.0T steady-state free-precession (FISP) and fast low-angle shot (FLASH) dynamic contrast myocardial perfusion images, arterial input function (AIF) images, and proton density (PD)-weighted images acquired under breath-hold (BH) and free-breath (FB) settings.<bold>Results: </bold>Our method significantly improved frame-to-frame appearance consistency compared to raw series, expressed in correlation coefficient (R2 = 0.996 ± 3.735E-3 vs. 0.978 ± 2.024E-2, P < 0.0001) and mutual information (3.823 ± 4.098E-1 vs. 2.967 ± 4.697E-1, P < 0.0001). It is applicable to both BH (R2 = 0.998 ± 3.217E-3 vs. 0.990 ± 7.527E-3) and FB (R2 = 0.995 ± 3.410E-3 vs. 0.968 ± 2.257E-3) paradigms as well as FISP and FLASH sequences. The method registers PD images to perfusion T1 series (9.70% max increase in R2 vs. no registration, P < 0.001) and also corrects motion in low-resolution AIF series (R2 = 0.987 ± 1.180E-2 vs. 0.964 ± 3.860E-2, P < 0.001). Finally, we showed the myocardial perfusion contrast dynamic was preserved in the motion-corrected images compared to the raw series (R2 = 0.995 ± 6.420E-3).<bold>Conclusion: </bold>The critical step of motion correction prior to pixel-wise cardiac MR perfusion quantification can be performed with the proposed universal system. It is applicable to a wide range of perfusion series and auxiliary images with different acquisition settings.<bold>Level Of Evidence: </bold>3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1060-1072.
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 46, Issue 4, p1060
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25659