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- Title
Inter-study reproducibility of left ventricular torsion and torsion rate quantification using MR myocardial feature tracking.
- Authors
Kowallick, Johannes T.; Morton, Geraint; Lamata, Pablo; Jogiya, Roy; Kutty, Shelby; Lotz, Joachim; Hasenfuß, Gerd; Nagel, Eike; Chiribiri, Amedeo; Schuster, Andreas; Hasenfuß, Gerd
- Abstract
<bold>Background: </bold>To determine the inter-study reproducibility of MR feature tracking (MR-FT) derived left ventricular (LV) torsion and torsion rates for a combined assessment of systolic and diastolic myocardial function.<bold>Methods: </bold>Steady-state free precession (SSFP) cine LV short-axis stacks were acquired at 9:00 (Exam A), 9:30 (Exam B), and 14:00 (Exam C) in 16 healthy volunteers at 3 Tesla. SSFP images were analyzed offline using MR-FT to assess rotational displacement in apical and basal slices. Global peak torsion, peak systolic and peak diastolic torsion rates were calculated using different definitions ("twist", "normalized twist" and "circumferential-longitudinal (CL) shear angle"). Exam A and B were compared to assess the inter-study reproducibility. Morning and afternoon scans were compared to address possible diurnal variation.<bold>Results: </bold>The different methods showed good inter-study reproducibility for global peak torsion (intraclass correlation coefficient [ICC]: 0.90-0.92; coefficient of variation [CoV]: 19.0-20.3%) and global peak systolic torsion rate (ICC: 0.82-0.84; CoV: 25.9-29.0%). Conversely, global peak diastolic torsion rate showed little inter-study reproducibility (ICC: 0.34-0.47; CoV: 40.8-45.5%). Global peak torsion as determined by the CL shear angle showed the best inter-study reproducibility (ICC: 0.90;CoV: 19.0%). MR-FT results were not measurably affected by diurnal variation between morning and afternoon scans (CL shear angle: 4.8 ± 1.4°, 4.8 ± 1.5°, and 4.1 ± 1.6° for Exam A, B, and C, respectively; P = 0.21).<bold>Conclusion: </bold>MR-FT based derivation of myocardial peak torsion and peak systolic torsion rate has high inter-study reproducibility as opposed to peak diastolic torsion rate. The CL shear angle was the most reproducible parameter independently of cardiac anatomy and may develop into a robust tool to quantify cardiac rotational mechanics in longitudinal MR-FT patient studies.
- Subjects
HEART ventricle diseases; COMPARATIVE studies; DIAGNOSTIC imaging; LEFT heart ventricle; INFORMATION science; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; RESEARCH; RESEARCH evaluation; RESEARCH funding; EVALUATION research; RESEARCH bias; TORSION abnormality (Anatomy)
- Publication
Journal of Magnetic Resonance Imaging, 2016, Vol 43, Issue 1, p128
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.24979