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- Title
In vivo relaxation behavior of liver compounds at 7 tesla, measured by single-voxel proton MR spectroscopy.
- Authors
Gajdošík, Martin; Chmelík, Marek; Just‐Kukurová, Ivica; Bogner, Wolfgang; Valkovič, Ladislav; Trattnig, Siegfried; Krššák, Martin
- Abstract
Purpose To assess the proton T1 and T2 relaxation of in vivo hepatic water, choline and lipid resonances with possible J-coupling behavior of lipids in healthy volunteers at 7 Tesla (T). Materials and Methods Relaxation measurements were conducted on corn oil phantoms and on the hepatic tissue of 11 healthy volunteers at 7 T using a surface coil and a STEAM sequence. T1's were determined by monoexponential fitting, and T2's by both monoexponential and enhanced-exponential fitting (empirically designed to consider J-coupling of lipid resonances). Results In vivo T1's at 7 T were estimated as follows: water (4.70 ppm), 1362 ± 83 ms; methyl- (0.90 ppm), 1026 ± 162 ms; methylene- (1.30 ppm), 514 ± 25 ms; α-olefinic- (2.02 ppm), 488 ± 220 ms; α-carboxyl- (2.24 ppm), 476 ± 89 ms; diacyl- (2.77 ppm), 479 ± 260 ms group of lipid chains; and choline compounds (3.22 ppm), 1084 ± 52 ms. The T2's calculated with enhanced fitting were as follows: water, 15 ± 2 ms; methyl-, 34 ± 10 ms; methylene-, 41 ± 8 ms; α-olefinic-, 44 ± 19 ms; α-carboxyl-, 39 ± 15 ms; diacyl-, 44 ± 5 ms group of lipid chains; and choline compounds, 32 ± 9 ms. Conclusion An accurate knowledge of in vivo relaxation and J-coupling behavior will significantly improve the quantification of an extended number of resolved liver metabolites at 7 T. J. Magn. Reson. Imaging 2014;40:1365-1374. © 2013 Wiley Periodicals, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2014, Vol 40, Issue 6, p1365
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.24489