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- Title
The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2.
- Authors
Ben-Chetrit, Eldad; Fischel, Ruth; Hinz, Burkhard; Levy, Micha
- Abstract
Objective: The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX). Methods: Measurement of COX- 1 and COX-2 activity was performed by using whole blood assay. Serum thromboxane (TXA) and plasma prostaglandin 2 (PGE2) levels were determined using a commercially available enzyme immunoassay kit. Celecoxib, etodolac, and nimesulide were also tested as controls. Since the study was intended to find a qualitative effect rather than a quantitative relationship between the drugs and the enzymes, we used higher concentrations than the therapeutic range. Results: Colchicine did not have an inhibitory effect on cyclo-oxygenases. Hydroxychloroquine had a mild inhibitory effect in a relatively high concentration. As expected, celecoxib, etodolac, and nimesulide did have an inhibitory effect on the cyclo-oxygenases. Conclusions: Neither colchicine nor hydroxychloroquine exert their anti-inhibitory effect through inhibition of cyclo-oxygenases.
- Subjects
COLCHICINE; NONSTEROIDAL anti-inflammatory agents; BLOOD plasma; ENZYMES; CYCLOOXYGENASE 2 inhibitors; SERUM; ENZYME-linked immunosorbent assay
- Publication
Rheumatology International, 2005, Vol 25, Issue 5, p332
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-004-0442-4