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- Title
5-Aryl-1-Arylideneamino-1 H -Imidazole-2(3 H)-Thiones: Synthesis and In Vitro Anticancer Evaluation.
- Authors
Abu Almaaty, Ali H.; Toson, Eslam E. M.; El-Sayed, El-Sherbiny H.; Tantawy, Mohamed A. M.; Fayad, Eman; Abu Ali, Ola A.; Zaki, Islam; Csuk, René
- Abstract
A novel series of N-1 arylidene amino imidazole-2-thiones were synthesized, identified using IR, 1H-NMR, and 13C-NMR spectral data. Cytotoxic effect of the prepared compounds was carried out utilizing three cancer cell lines; MCF-7 breast cancer, HepG2 liver cancer, and HCT-116 colon cancer cell lines. Imidazole derivative 5 was the most potent of all against three cell lines. DNA flow cytometric analysis showed that, imidazoles 4d and 5 exhibit pre-G1 apoptosis and cell cycle arrest at G2/M phase. The results of the VEGFR-2 and B-Raf kinase inhibition assay revealed that compounds 4d and 5 displayed good inhibitory activity compared with reference drug erlotinib.
- Subjects
ERLOTINIB; CELL cycle; CELL lines; LIVER cancer; CANCER cells; COLON cancer
- Publication
Molecules, 2021, Vol 26, Issue 6, p1706
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26061706