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- Title
Chromobacterium violaceum and Pseudomonas aeruginosa PAO1: Models for Evaluating Anti-Quorum Sensing Activity of Melaleuca alternifolia Essential Oil and Its Main Component Terpinen-4-ol.
- Authors
Noumi, Emira; Merghni, Abderrahmen; M. Alreshidi, Mousa; Haddad, Ons; Akmadar, Gültekin; De Martino, Laura; Mastouri, Maha; Ceylan, Ozgur; Snoussi, Mejdi; Al-sieni, Abdulbasit; De Feo, Vincenzo
- Abstract
The problem of antibiotic resistance among pathogens encourages searching for novel active molecules. The aim of the research was to assay the anti-quorum sensing (anti-QS) and antibiofilm potential of Melaleuca alternifolia essential oil and its main constituent, terpinen-4-ol, to prevent the infections due to methicillin-resistant Staphylococcus aureus strains as an alternate to antibiotics. The tea tree oil (TTO) was evaluated for its potential in inhibiting QS-dependent phenomena such as violacein production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1, and biofilm formation in MRSA strains on glass. The results showed that terpinen-4-ol was able to inhibit MRSA strain biofilm formation on the glass strips by 73.70%. TTO inhibited the violacein production at a mean inhibitory concentration (MIC) value of 0.048 mg/mL by 69.3%. At 100 µg/mL TTO and terpinen-4-ol exhibited inhibition in swarming motility of PAO1 by 33.33% and 25%, respectively. TTO revealed anti-QS and anti-biofilm activities at very low concentrations, but it could be further investigated for new molecules useful for the treatment of MRSA infections.
- Subjects
DRUG resistance; CHROMOBACTERIUM violaceum; ANTIBIOTICS; PATHOGENIC microorganisms; MELALEUCA alternifolia; PSEUDOMONAS aeruginosa; VIOLACEIN; METHICILLIN-resistant staphylococcus aureus
- Publication
Molecules, 2018, Vol 23, Issue 10, p2672
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23102672