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- Title
Organic-Inorganic Hybrid Nanoparticles for Bacterial Inhibition: Synthesis and Characterization of Doped and Undoped ONPs with Ag/Au NPs.
- Authors
Huerta Aguilar, Carlos Alberto; Pérez Jiménez, Adriana Berenice; Romero Silva, Antonio; Kaur, Navneet; Thangarasu, Pandiyan; Ramos, Jorge Manuel Vázquez; Singh, Narinder
- Abstract
Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi). Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was analyzed by molecular orbital and density of state (DOS) using DFT.
- Subjects
NANOPARTICLES; SILVER compounds; LIPOIC acid; SALMONELLA typhi; STAPHYLOCOCCUS aureus
- Publication
Molecules, 2015, Vol 20, Issue 4, p6002
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules20046002