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- Title
The Role of Selected Flavonols in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor–1 (TRAIL-R1) Expression on Activated RAW 264.7 Macrophages.
- Authors
Warat, Monika; Sadowski, Tadeusz; Szliszka, Ewelina; Król, Wojciech; Czuba, Zenon P.
- Abstract
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptors (TRAIL-R) are an important factor of apoptosis in cancer cells. There are no data about the effect of flavonols on the receptor expression on a surface of macrophage like cells. In this study, the expression level of TRAIL-R1 on murine RAW264.7 macrophages in the presence of selected flavonols: galangin, kaempferol, kaempferide and quercetin, which differ from their phenyl ring substituents, were studied. The expression of TRAIL-R1 death receptors on non-stimulated and lipopolysaccharide (LPS)-stimulated macrophages was determined using flow cytometry. The results suggested that compounds being tested can modulate TRAIL-R1 expression and can enhance TRAIL-mediated apoptosis.
- Subjects
FLAVONOLS; TUMOR necrosis factors; APOPTOSIS; MACROPHAGES; CANCER cells; LIPOPOLYSACCHARIDES; FLOW cytometry
- Publication
Molecules, 2015, Vol 20, Issue 1, p900
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules20010900