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- Title
Flow Cytometric DNA Histograms of Paraffin-Embedded Pheochromocytomas.
- Authors
Hosaka, Y.; Aso, Y.; Rainwater, L.M.; Grant, C.S.; Farrow, G.M.; van Heerden, J.A.; Lieber, M.M.
- Abstract
We proposed a new classification of pheochromocytomas according to DNA ploidy patterns. Proliferation index (PI = S% + 4C%) might be an alternative to 4C% which was used as a critical marker of DNA nonaneuploid histograms. The follow-up survey revealed that DNA tetraploid with minimum increase of PI could not rule out the substantial possibility of malignancy and the comparison of DNA diploid histograms disclosed that 22 and 0% showed significant increase of the ratio of 4C% to S% under PI and 4C% criteria, respectively. In conclusion, 4C% was more effective and reliable than PI in order to classify DNA nonaneuploid pheochromocytomas. Copyright © 1991 S. Karger AG, Basel
- Publication
Urologia Internationalis, 1991, Vol 47, Issue S1, p100
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000282264