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- Title
The Search for Single-Domain Antibodies Interacting with the Receptor-Binding Domain of SARS-CoV-2 Surface Protein.
- Authors
Aripov, V. S.; Volkova, N. V.; Taranin, A. V.; Mechetina, L. V.; Chikaev, N. A.; Nayakshin, A. M.; Nesmeyanova, V. S.; Isaeva, A. A.; Merkul'eva, Yu. A.; Shanshin, D. V.; Belenkaya, S. V.; Ilyichev, A. A.; Shcherbakov, D. N.
- Abstract
We performed a search for nanoantibodies that specifically interact with the receptor-binding domain (RBD) of the SARS-CoV-2 surface protein. The specificity of single-domain antibodies from the blood sera of a llama immunized with RBD of SARS-CoV-2 surface protein S (variant B.1.1.7 (Alpha)) was analyzed by ELISA. Recombinant trimers of the SARS-CoV-2 spike protein were used as antigens. In this work, a set of single-domain antibodies was obtained that specifically bind to the RBD of the SARS-CoV-2 virus.
- Subjects
SARS-CoV-2; PROTEIN S; PROTEINS; IMMUNOGLOBULINS
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 175, Issue 2, p225
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-023-05839-6