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- Title
Correcting Effect of Ladasten on Variations in the Subpopulation Composition of T Lymphocytes in C57Bl/6 Mice on the Experimental Model of an Anxious-Depressive State.
- Authors
Tallerova, A.; Kovalenko, L.; Kuznetsova, O.; Durnev, A.; Seredenin, S.
- Abstract
We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4/CD8 ratio toward cytotoxic T cells. Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
- Subjects
T cell receptors; LABORATORY rats; T cells; IMMUNOCOMPETENT cells; PHYSIOLOGY
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 156, Issue 3, p335
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2343-1