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- Title
Morphofunctional Characteristics of Fibroblasts and Fibrogenesis in the Lungs of Mice Infected with Influenza A/H5N1 A/Goose/Krasnoozerskoye/627/05 Virus.
- Authors
Anikina, A.; Potapova, O.; Shkurupy, V.
- Abstract
Mice C57Bl/6 were intranasally infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The expression of influenza A virus antigen in the lung interstitium fibroblasts was recorded during all periods of the study (on days 1-14 after infection), the maximum expression on days 1 and 3. On day 1, the volume density of collagen fibers in the lungs was 3-fold higher than in intact animals; by day 14 it increased almost 15-fold. The numerical density of PCNA+ fibroblasts increased almost 2-fold from day 1 to day 10; 'fibroplastic activity' of fibroblasts increased more than 3-fold.
- Subjects
H5N1 Influenza; INFLUENZA A virus, H5N1 subtype; LUNG diseases; FIBROSIS; FIBROBLASTS; COLLAGEN
- Publication
Bulletin of Experimental Biology & Medicine, 2013, Vol 154, Issue 3, p361
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-013-1951-5