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- Title
New insights on occupational exposure and bladder cancer risk: a pooled analysis of two Italian case-control studies.
- Authors
Sciannameo, Veronica; Carta, Angela; d'Errico, Angelo; Giraudo, Maria Teresa; Fasanelli, Francesca; Arici, Cecilia; Maule, Milena; Carnà, Paolo; Destefanis, Paolo; Rolle, Luigi; Gontero, Paolo; Casetta, Giovanni; Zitella, Andrea; Cucchiarale, Giuseppina; Vineis, Paolo; Porru, Stefano; Sacerdote, Carlotta; Ricceri, Fulvio
- Abstract
Purpose: The main risk factor for bladder cancer (BC) is cigarette smoking, but also occupational exposure to carcinogens is relevant, causing about 4-10% of BC. We aimed at investigating the association between BC risk, occupations held in the past and exposure to occupational carcinogens, also assessing whether these associations were influenced by tumour grade.Methods: We pooled data from two Italian case-control studies on male BC, analyzing 893 cases and 978 controls. Occupations were classified using the International Standard Classification of Occupations and exposure to carcinogens was assigned using a validated Job Exposure Matrix. Logistic regression approach was used as well as a semi-Bayesian model, based on a priori information on exposure.Results: A significantly increased BC risk was found for chemical engineering technicians, postmen, and lathe operators, but only, for the latter, the association remained significant after Bayesian control for type I error. Among carcinogens, cadmium and trichloroethylene were associated with BC. When analyzing data by grade, exposure to these carcinogens was associated with low-grade BC only.Conclusions: Our results suggest that monitoring workplaces to prevent exposure to carcinogenic agents is still an important task, which should be still given adequate importance in public health.
- Subjects
BLADDER cancer risk factors; CARCINOGENS; INDUSTRIAL hygiene; TRICHLOROETHYLENE; CADMIUM
- Publication
International Archives of Occupational & Environmental Health, 2019, Vol 92, Issue 3, p347
- ISSN
0340-0131
- Publication type
Article
- DOI
10.1007/s00420-018-1388-2