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- Title
Biological effects of grape stem extracts on human cancer cell lines.
- Authors
Vassi, Eleni; Veskoukis, Aristidis S.; Tekos, Fotios; Skaperda, Zoi; Poulas, Konstantinos; Haroutounian, Serkos; Kouretas, Demetrios
- Abstract
Grapes are rich in polyphenolic compounds, which are known for their beneficial effects on human health. Grape stems are byproducts of the winemaking procedure. They exert antioxidant effects; however, they can also become pollutants when discarded without control into the environment due to their high organic content. The main aim of the present study was to examine the potential prooxidant/anticancer effects of grape stem extracts, promoting the rationale of the scientific exploitation of such compounds. Therefore, three grape stem extracts derived from the native Greek vine varieties, Mavrodaphne, Muscat and Rhoditis were examined for their ability to alter the redox status [i.e., endogenous levels of reduced glutathione and reactive oxygen species (ROS)] of HeLa and HepG2 human cancer cell lines. The results revealed that the extracts from Muscat and Rhoditis exerted prooxidant effects on the tested cell lines, whereas the extract of Mavrodaphne did not exert any such effects. The fact that the extracts functioned as prooxidants appears to be detrimental for the cancer cells, since they are more susceptible to high concentrations of ROS, contrary to healthy cells that possess more robust antioxidant defense mechanisms. On the whole, as demonstrated in the present study, it appears that the Muscat and Rhoditis extracts may prove to be promising agents against cancer cells in the specific in vitro model. However, further studies are required to confirm these findings, in in vivo settings.
- Subjects
TUMOR prevention; GLUTATHIONE; IN vitro studies; POLYPHENOLS; GRAPES; ANTINEOPLASTIC agents; ANTIOXIDANTS; CELL survival; TREATMENT effectiveness; PLANT stems; FLAVONOLS; DESCRIPTIVE statistics; PLANT extracts; CELL lines; REACTIVE oxygen species; OXIDATION-reduction reaction
- Publication
International Journal of Functional Nutrition, 2022, Vol 3, Issue 3, pN.PAG
- ISSN
2634-7989
- Publication type
Article
- DOI
10.3892/ijfn.2022.27