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- Title
Inverse Association of Prostatic Chronic Inflammation among Prostate Cancer Tumor Grade Groups: Retrospective Study of 738 Consecutive Cases Elected to a First Random Biopsy Set.
- Authors
Porcaro, Antonio Benito; Tafuri, Alessandro; Novella, Giovanni; Sebben, Marco; Mariotto, Arianna; Inverardi, Davide; Corsi, Paolo; Processali, Tania; Pirozzi, Marco; Amigoni, Nelia; Rizzetto, Riccardo; Brunelli, Matteo; Balzarro, Matteo; Siracusano, Salvatore; Artibani, Walter
- Abstract
<bold><italic>Objectives:</italic></bold> The study aimed to evaluate associations of prostatic chronic inflammation (PCI) with prostate cancer (PCA) grade groups by the International Society of Urological Pathology (ISUP). <bold><italic>Methods:</italic></bold> The study evaluated retrospectively 738 cases. The patient population was sampled into 3 groups collecting cases without and with PCA including subjects with lSUP grade group 1 and grade groups 2–5. <bold><italic>Results:</italic></bold> PCI was assessed in 185 patients (25.1%) and PCA in 361 patients (48.9%) of whom 188 (25.5%) had ISUP grade and 173 (23.4%) had ISUP groups 2–5 tumors. PCI inversely related to ISUP groups (<italic>p</italic> < 0.0001). In multivariate analysis, the risk of ISUP grade group 1 PCA compared to negative cases associated positively with age (OR 1.042; <italic>p</italic> = 0.001) but inversely with total prostate volume (TPV; OR 0.965; <italic>p</italic> < 0.0001) and PCI (OR 0.314; <italic>p</italic> < 0.0001). Intermediate-high grade tumors associated positively with age (OR 1.065; <italic>p</italic> < 0.0001), prostate specific antigen (OR 1.167; <italic>p</italic> < 0.0001), and abnormal digital rectal examination (OR 2.251; <italic>p</italic> < 0.0001) but inversely with TPV (OR 0.921; <italic>p</italic> < 0.0001) and PCI (OR 0.106; <italic>p</italic> < 0.0001). <bold><italic>Conclusions:</italic></bold> PCI decreased the risk of PCA among ISUP tumor grade groups.
- Subjects
DIAGNOSIS; PROSTATE cancer; PROSTATE disease diagnosis; PROSTATE cancer treatment; PROSTATE-specific antigen; UROLOGY
- Publication
Urologia Internationalis, 2018, Vol 100, Issue 4, p456
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000488882