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- Title
Resolution of Cheyne-Stokes Respiration after Treatment of Heart Failure with Sacubitril/Valsartan: A First Case Report.
- Authors
Fox, Henrik; Bitter, Thomas; Horstkotte, Dieter; Oldenburg, Olaf
- Abstract
Sleep-disordered breathing (SDB) is highly prevalent in patients with heart failure (HF), and is known to be associated with a worse prognosis. The severity of central sleep apnea is thought to mirror cardiac dysfunction. The novel angiotensin receptor-neprilysin inhibitor (ARNi) sacubitril has been shown to improve HF, but a relationship between treatment with ARNi and the severity of SDB has not yet been investigated. We report the case of a 71-year-old male with HF and SDB. Treatment with sacubitril/valsartan was associated with improved cardiac function, as shown by a reduction in the level of N-terminal prohormone of brain natriuretic peptide from 3,249 to 1,720 pg/mL and an improvement in left-ventricular ejection fraction from 30 to 35%. This was accompanied by a marked reduction in the apnea-hypopnea index (from 41 to 19/h). To the best of our knowledge, this is the first case to document parallel improvements in HF and SDB after the initiation of ARNi treatment.
- Subjects
SLEEP apnea syndromes; CHEYNE-Stokes respiration; HEART failure treatment; VALSARTAN; ANGIOTENSINS; PATIENTS
- Publication
Cardiology, 2017, Vol 137, Issue 2, p96
- ISSN
0008-6312
- Publication type
Case Study
- DOI
10.1159/000455118