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- Title
Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment.
- Authors
Stashkevich, M.; Khomutov, E.; Dumanskii, Yu.; Matvienko, A.; Zinkovich, I.
- Abstract
Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.
- Subjects
URACIL antagonists; FLUOROPYRIMIDINES; PYRIMIDINE nucleosides; GLYCOSYLTRANSFERASES; THYMIDINE phosphorylase
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 160, Issue 5, p646
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3239-z