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- Title
Planar cell polarity: one or two pathways?
- Authors
Lawrence, Peter A.; Struhl, Gary; Casal, José; Casal, José
- Abstract
In multicellular organisms, cells are polarized in the plane of the epithelial sheet, revealed in some cell types by oriented hairs or cilia. Many of the underlying genes have been identified in Drosophila melanogaster and are conserved in vertebrates. Here we dissect the logic of planar cell polarity (PCP). We review studies of genetic mosaics in adult flies - marked cells of different genotypes help us to understand how polarizing information is generated and how it passes from one cell to another. We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field.
- Subjects
CELL polarity; DROSOPHILA melanogaster; GENETIC polymorphisms; DIPTERA; HEREDITY; GENETICS; ANIMAL experimentation; BIOLOGICAL models; CELL physiology; CELLS; CELLULAR signal transduction; COMPARATIVE studies; INSECTS; RESEARCH methodology; MEDICAL cooperation; MICE; MORPHOGENESIS; RESEARCH; EVALUATION research
- Publication
Nature Reviews Genetics, 2007, Vol 8, Issue 7, p555
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg2125