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- Title
Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.
- Authors
van der Pouw Kraan, T C T M; Küçükaycan, M; Bakker, A M; Baggen, J M C; van der Zee, J S; Dentener, M A; Wouters, E F M; Verweij, C L
- Abstract
IL-13 is strongly implicated in the development of asthma and chronic obstructive polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P = 0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P = 0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P = 0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P = 0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD.
- Subjects
OBSTRUCTIVE lung diseases; INTERLEUKINS; GENETIC polymorphisms; GENETICS
- Publication
Genes & Immunity, 2002, Vol 3, Issue 7, p436
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6363896