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- Title
A koraszülés, intrauterin növekedési retardáció, preeclampsia és vetélés sikeres megelőzése az ovulációs ciklusok hormonális rendezésével.
- Authors
György, Siklósi; Nándor, Ács; Ferenc, Bánhidy
- Abstract
Background: We elaborated a hormonal method which can quantitatively characterize ovulatory menstrual cycles (folliculo-luteal function, FLF). In this paper, we analyze the association between FLF and pregnancy outcome in the management of infertility of unknown origin (UI) and also the extent to which preconception physiology of FLF can prevent preterm delivery, IUGR, preeclampsia and miscarriage. Patients and methods. We analyzed data from 884 pregnancies of 658 patients treated for UI (2–17, mean 4.4 years of infertility). Progesterone (P) mean values measured during the luteal phase of pregnancies resulting in singular, mature and eutrophic newborn we considered as physiological. We normalized FLF by controlled clomiphene citrate and/or low dose corticoid treatment before conception. Results: We found a strong and significant correlation between the luteal P (r=0.83) and E2 values and the length of pregnancy (weeks). A strong correlation was also detected between the luteal P and E2 values and the weight (r=0.84) and other parameters of newborns. Based on the outcome of pregnancy, three grades of folliculo-luteal insufficiency (FLI) can be differentiated: • Physiological FLF: P>23 ng/ml, singular, mature and eutrophic birth, • FLI grade I: P 17–23 ng/ml, preterm birth, IUGR, preeclampsia, • FLI grade II: P 11–17 ng/ml, miscarriage, • FLI grade III: P <11 ng/ml, inability to conceive. Conclusions: The outcome of pregnancy is largely determined by the FLF. With the preconceptional physiology of FLF, the incidence of preterm birth is 0.7% (late preterm births with weight above 2300 g) IUGR 0.7% (mature births above 2000 g), preeclampsia 0% and miscarriage were reduced from approximately 20% to 3.4%
- Publication
Magyar Nőorvosok Lapja, 2024, Vol 87, Issue 2, p83
- ISSN
0025-021X
- Publication type
Article