We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
469 Diverse Role of blaCTX-M and Porins in Mediating Ertapenem Resistance Among Carbapenem Resistant Enterobacterales.
- Authors
Black, Cody; Black, Cody A.; Benavides, Raymond; Bandy, Sarah M.; Dallas, Steven S.; Gawrys, Gerard; So, Wonhee; Moreira, Alvaro G.; Aguilar, Samantha; Quidilla, Kevin; Smelter, Dan F.; Reveles, Kelly R.; Frei, Christopher R.; Koeller, Jim M.; Lee, Grace C.
- Abstract
This document is an abstract from the Journal of Clinical & Translational Science. The first part of the abstract discusses a study on the role of blaCTX-M and porins in mediating ertapenem resistance among carbapenem-resistant Enterobacterales (CRE) subtypes. The study used whole genome sequencing to analyze 76 carbapenem-resistant isolates and found that blaCTX-M was most prevalent among non-carbapenemase producing Enterobacterales (NCPE) strains. The study also found that E. coli strains were driving the ertapenem-resistant but meropenem-susceptible (ErMs) phenotype. The second part of the abstract discusses a study on associations between gene-transcript expressions in cocaine use disorder (CUD) and other substance use and cardio-neurovascular disease. The study used blood-based transcriptomics to investigate how clinical conditions relate to CUD and found genetic predispositions towards certain clinical conditions and substance use traits. The study also found significant baseline differences in predisposition to small vessel ischemic stroke in responders with high vs low perceived stress. Overall, these studies provide insights into the mechanisms of antibiotic resistance and genetic predispositions in CUD.
- Publication
Journal of Clinical & Translational Science, 2024, Vol 8, p138
- ISSN
2059-8661
- Publication type
Abstract
- DOI
10.1017/cts.2024.397