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- Title
Factor II- and factor Xa-inhibitors for prevention and treatment of thromboses.
- Authors
Orth M
- Abstract
The desired properties of an ideal anticoagulant should be reliable action, a defined, selective mode of action, a wide therapeutic window, and predictable pharmacokinetics. Numerous new substances were developed as a substitute for oral anticoagulants and heparins. Owing to their superiority in clinical studies, some of these drugs have already been approved. The hemostaseological laboratory is now challenged to detect a sufficient anticoagulation while avoiding bleeding by overdosing. The purpose of this review is to describe novel anticoagulants in current use and the possible tests for drug monitoring in heparin-induced thrombocytopenia and in the perioperative prevention of thromboses.
- Publication
Journal of Laboratory Medicine / Laboratoriums Medizin, 2009, Vol 33, Issue 2, p121
- ISSN
0342-3026
- Publication type
Journal Article
- DOI
10.1515/JLM.2009.023