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- Title
Qualitätskontrolle in der Liquordiagnostik: Anmerkungen zur Analyse von Proteinen und Interpretation von Liquor/Serum-Konzentrationsquotienten sowie zu Formeln bei der Diagnostik der Blut/Liquor-Schranken-Funktion und intrathekalen Immunglobulinproduktion.
- Authors
Kleine, T. O.
- Abstract
Guidelines for quality assurance of CSF protein analysis of the German Society for CSF Diagnosis and Clinical Neurochemistry (DGLN) give cause to compare principles of external quality assurance of CSF proteins carried out by DGLN and the German United Society for Clinical Chemistry and Laboratory Diagnosis (DGKL). It is stated that CSF/serum concentration gradients Q of albumin, IgG, IgA, IgM were analysed in a method-dependent way; they are modelled by some effectors e.g. sample quantity, content of the proteins in CSF and blood, as well as by impairments such as artificial blood contamination. The effectors also affect QAlbumin, a parameter of blood/CSF function. QAlbumin also represents the variable of the hyperbolic functions to quantify intrathecally synthesized IgG, IgA, IgM; the index formulae evaluate QAlbumin in relation to QIgG, QIgA, and QIgM, respectively, to estimate the intrathecal immunoglobulins (Ig) with quality assurance of DGKL. Comparisons of both procedures to estimate intrathecal Ig indicate the hyperbolic functions, propagated by DGLN, to be too insensitive with respect to index formulae; both procedures, however, detect less intrathecal Ig compared to semi-quantitative procedures for the detection of oligoclonal IgG, IgA, IgM.
- Publication
Journal of Laboratory Medicine / Laboratoriums Medizin, 2004, Vol 28, Issue 1, p6
- ISSN
0342-3026
- Publication type
Article