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- Title
Protein based devices for oral tissue repair and regeneration.
- Authors
Cruz-Maya, Iriczalli; Guarino, Vincenzo; Alvarez-Perez, Marco Antonio
- Abstract
In the last decades, a goal of tissue engineering has been devoted to the design of devices with multiple micro- or nano-structures and loaded with bioactive molecules, to mimic the extracellular matrix (ECM) so generating a conducive microenvironment for new tissue replacement/regeneration. The ECM, naturally, is composed of fibrous proteins which provide structural support for tissues, mainly regulating cells behavior in terms of proliferation, growth, survival, shape, migration and differentiation by cell-matrix interactions. Several studies have been just investigated the fabrication of different platforms for the regeneration of teeth, oral mucosa, salivary glands, bone, and periodontium. In this context, many proteins--from a natural or biological source--have been used as instructive substances to in vitro guide tissue organization and functions. In particular, new advances in the definition of protein-based formulations currently represent a great challenge to promote a more effective regeneration of dental tissues to be transplanted into patients to replace damaged, diseased or missing tissues. Hence, the purpose of this review is to discuss the use of protein-based systems for the regeneration of oral tissues.
- Subjects
TISSUE engineering; EXTRACELLULAR matrix; CELL proliferation
- Publication
AIMS Materials Science, 2018, Vol 5, Issue 2, p156
- ISSN
2372-0468
- Publication type
Article
- DOI
10.3934/matersci.2018.2.156