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- Title
Estimation of Small-Scale Kinetic Parameters of Escherichia coli (E. coli) Model by Enhanced Segment Particle Swarm Optimization Algorithm ESe-PSO.
- Authors
Azrag, Mohammed Adam Kunna; Zain, Jasni Mohamad; Kadir, Tuty Asmawaty Abdul; Yusoff, Marina; Jaber, Aqeel Sakhy; Abdlrhman, Hybat Salih Mohamed; Ahmed, Yasmeen Hafiz Zaki; Husain, Mohamed Saad Bala
- Abstract
The ability to create "structured models" of biological simulations is becoming more and more commonplace. Although computer simulations can be used to estimate the model, they are restricted by the lack of experimentally available parameter values, which must be approximated. In this study, an Enhanced Segment Particle Swarm Optimization (ESe-PSO) algorithm that can estimate the values of small-scale kinetic parameters is described and applied to E. coli's main metabolic network as a model system. The glycolysis, phosphotransferase system, pentose phosphate, the TCA cycle, gluconeogenesis, glyoxylate pathways, and acetate formation pathways of Escherichia coli are represented by the Differential Algebraic Equations (DAE) system for the metabolic network. However, this algorithm uses segments to organize particle movements and the dynamic inertia weight (ω) to increase the algorithm's exploration and exploitation potential. As an alternative to the state-of-the-art algorithm, this adjustment improves estimation accuracy. The numerical findings indicate a good agreement between the observed and predicted data. In this regard, the result of the ESe-PSO algorithm achieved superior accuracy compared with the Segment Particle Swarm Optimization (Se-PSO), Particle Swarm Optimization (PSO), Genetic Algorithm (GA), and Differential Evolution (DE) algorithms. As a result of this innovative approach, it was concluded that small-scale and even entire cell kinetic model parameters can be developed.
- Subjects
PARTICLE swarm optimization; ESCHERICHIA coli; MATHEMATICAL optimization; DIFFERENTIAL evolution; GENETIC algorithms
- Publication
Processes, 2023, Vol 11, Issue 1, p126
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr11010126