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- Title
Short-term outcomes of switching to brolucizumab in japanese patients with neovascular age-related macular degeneration.
- Authors
Kitajima, Yoko; Maruyama-Inoue, Maiko; Ikeda, Shoko; Ito, Arisa; Inoue, Tatsuya; Yanagi, Yasuo; Kadonosono, Kazuaki
- Abstract
Purpose: To evaluate the outcomes of a 6-month follow-up after switching to brolucizumab from aflibercept to treat neovascular age-related macular degeneration (AMD) in Japanese patients. Study design: Retrospective observational study. Methods: We studied 45 consecutive eyes of 42 patients diagnosed with neovascular AMD, who were switched to intravitreal brolucizumab injection (IVBr) after receiving intravitreal aflibercept injection (IVA) using a treat-and-extend (TAE) regimen. Patients who had brolucizumab-associated intraocular inflammation (IOI) were excluded from the study. The mean changes in the logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), central foveal thickness (CFT), central choroidal thickness (CCT), and treatment intervals were evaluated at 6 months after the switch to IVBr. Results: One eye of 1 patient was excluded because of IOI after the switch; 44 eyes of 41 patients were enrolled in this study. The mean logMAR BCVA was maintained throughout the follow-up period when compared with the baseline value (P >.05 at 6 months). However, the mean CFT and CCT at 6 months had decreased significantly (P <.05 and P <.001, respectively). The mean treatment interval was extended from 5.75 to 8.12 weeks. Conclusion: Switching to brolucizumab from aflibercept using a TAE regimen might be effective for maintaining functional outcomes and extending intervals in Japanese patients with AMD.
- Subjects
MACULAR degeneration; JAPANESE people; INTRAVITREAL injections; CHOROID; EYE inflammation; POLYPOIDAL choroidal vasculopathy
- Publication
Japanese Journal of Ophthalmology, 2022, Vol 66, Issue 6, p511
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-022-00940-1