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- Title
Acute effect of pseudoephedrine on macular microcirculation in healthy subjects: an optical coherence tomography angiography study.
- Authors
Tuncer, Ibrahim; Unsal, Ugur
- Abstract
Purpose: To quantitatively evaluate the acute effects of pseudoephedrine on the macular microvasculature using optical coherence tomography angiography (OCTA). Study design: Randomized placebo-controlled clinical study. Methods: In this study, 60 right eyes of 60 healthy subjects were divided into 2 groups. The study group received 60 mg of pseudoephedrine and the control group received a placebo. All participants underwent OCTA at baseline and 1 h after oral intake. Superficial macular flow area, foveal avascular zone (FAZ), superficial macular vessel density, central foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) were analyzed. Results: Baseline superficial macular flow area, FAZ area, superficial macular vessel density, CFT and SFCT measurements in the study and control groups showed no significant difference (p > 0.05 for all). Oral pseudoephedrine intake caused a significant reduction in superficial macular flow area, FAZ area, superficial macular vessel density and SFCT measurements when compared with baseline (p < 0.05 for all). However, there was no significant difference in CFT after oral pseudoephedrine intake (p > 0.05). Conclusion: Oral pseudoephedrine intake causes a significant decrease in superficial macular blood flow and SFCT. Impairmant of macular microcirculation can be detected noninvasively and quantitavitely by OCTA.
- Subjects
OPTICAL coherence tomography; EPHEDRINE; ANGIOGRAPHY; MICROCIRCULATION; CHOROID
- Publication
Japanese Journal of Ophthalmology, 2022, Vol 66, Issue 1, p94
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-021-00859-z