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- Title
Wound healing fibroblasts modulate corneal angiogenic privilege: Interplay of basic fibroblast growth factor and matrix metalloproteinases in corneal angiogenesis.
- Authors
Chang, Jin-Hong; Han, Kyu Yeon; Azar, Dimitri T.
- Abstract
The article presents a review of a study on avascular wound healing of the cornea. Factors that contribute to avascularization of the cornea are discussed. Laboratory studies hypothesized that neovascularization (NV) or the formation of new vascular structures of the cornea can be promoted by means of stromal fibroblasts through their proangiogenic matrix metalloproteinase (MMP) activity. The activities of antiangiogenic and proangiogenic factors during wound healing are cited. The laboratory study used corneas harvested from mice.
- Subjects
WOUND healing; CORNEA injuries; NEOVASCULARIZATION; FIBROBLASTS; METALLOPROTEINASES
- Publication
Japanese Journal of Ophthalmology, 2010, Vol 54, Issue 3, p199
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-010-0801-5