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- Title
Initial temporal field defect in Leber hereditary optic neuropathy.
- Authors
Waki Fujie; Yuko Emoto
- Abstract
Abstract Purpose To determine the site of the initial field defect in patients with Leber hereditary optic neuropathy (LHON). Methods We studied nine eyes of nine consecutive LHON patients with the 11778 mitochondrial DNA mutation who had no visual loss (four eyes) or only minimal visual loss (five eyes). When unilateral visual loss was observed, Humphrey field analysis (HFA) (HFA 30–2 program and sometimes the HFA 10–2 program) was immediately and repeatedly performed on the better eye. Results For the 12 centralmost points in the visual field, a loss of sensitivity (P Conclusions The centralmost temporal visual field appears to be the most susceptible site in eyes of LHON patients. This suggests that the most susceptible cells during the early stages of LHON are the retinal ganglion cells located in the corresponding region of the retina.
- Subjects
OPTIC nerve diseases; VISUAL fields; RETINAL ganglion cells; RETINAL degeneration; MITOCHONDRIAL DNA abnormalities; NEUROPATHY; GENETIC mutation
- Publication
Japanese Journal of Ophthalmology, 2009, Vol 53, Issue 6, p603
- ISSN
0021-5155
- Publication type
Article