We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The research progress in the differentiation of osteoblasts/adipocytes by bone marrow mesenchymal stem cells and the effect of kidney-tonifying medicine.
- Authors
WANG Mingren; WU Chunbiao; ZHOU Xiaohong
- Abstract
Under the different induction conditions, bone marrow mesenchymal stem cells (MSCs) can differentiate to osteoblasts, chondrocytes, fibroblasts, adipocytes, and nerve cells. In the bone marrow microenvironment the relation between the bone and fat tissue formation is complicated. Both osteoblasts and adipocytes derive from MSCs. During the osteoblast and adipocyte differentiation, the possibility of transformation and plasticity exists. Bone mass loss in osteoporotic patients is associated with the increase of fat tissue in the bone marrow. It is related to imbalance of MSCs differentiation and to the over differentiation of adipocytes. According to the theory of Chinese medicine, the kidney governs bones and the marrow generates bones. It is believed that the deficiency of kidney essence is the key reason of osteoporosis. The kidney-tonifying medicine can influence the differentiation from MSCs to osteoblasts/adipocytes, therefore prevent the occurrence of osteoporosis.
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 10, p1240
- ISSN
1006-7108
- Publication type
Article