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- Title
Allelic expression ofIGF2in live-bearing, matrotrophic fishes.
- Authors
Lawton, Betty; Sevigny, Leila; Obergfell, Craig; Reznick, David; O’Neill, Rachel; O’Neill, Michael
- Abstract
The parental conflict, or kinship, theory of genomic imprinting predicts that parent-specific gene expression may evolve in species in which parental investment in developing offspring is unequal. This theory explains many aspects of parent-of-origin transcriptional silencing of embryonic growth regulatory genes in mammals, but it has not been tested in any other live-bearing, placental animals. A major embryonic growth promoting gene with conserved function in all vertebrates is insulin-like growth factor 2 (IGF2). This gene is imprinted in both eutherians and marsupials, as are several genes that modulateIGF2activity. We have tested for parent-of-origin influences on developmental expression ofIGF2in two poeciliid fish species,Heterandria formosaandPoeciliopsis prolifica, that have evolved placentation independently. We foundIGF2to be expressed bi-allelically throughout embryonic development in both species.
- Subjects
GENE expression; GENOMIC imprinting; FISHES; SOMATOMEDIN
- Publication
Development Genes & Evolution, 2005, Vol 215, Issue 4, p207
- ISSN
0949-944X
- Publication type
Article
- DOI
10.1007/s00427-004-0463-8