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- Title
Diffusion restriction on DWI of autoimmune glial fibrillary acidic protein astrocytopathy: a case report.
- Authors
Yao, Shengjun; Wang, Peng; Liu, Hualong; Cong, Lin; Liu, Xiaohui
- Abstract
This letter describes a case of glial fibrillary acidic protein astrocytopathy (GFAP-A), an autoimmune disease that affects the central nervous system. The patient presented with symptoms such as headache, confusion, and seizure, and was diagnosed with GFAP-A based on the presence of GFAP antibodies in the cerebrospinal fluid and serum. The imaging findings showed linear enhancement in the white matter, which is a characteristic feature of GFAP-A. Additionally, the patient exhibited diffusion restriction on diffusion-weighted imaging (DWI), which is a rare finding in GFAP-A. The patient responded well to treatment with intravenous immunoglobulin (IVIg) and corticosteroids. The diffusion restriction on DWI could be attributed to either inflammation caused by GFAP-A or complications associated with IVIg therapy. Overall, this case highlights the unique presentation of GFAP-A and the potential complications of treatment.
- Subjects
GLIAL fibrillary acidic protein; POSTERIOR leukoencephalopathy syndrome; CENTRAL nervous system diseases; CEREBRAL infarction; PUPILLARY reflex; BLOOD viscosity
- Publication
Neurological Sciences, 2024, Vol 45, Issue 6, p2915
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-024-07356-4