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- Title
Glucose and Counterregulatory Responses to Exercise in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia Using Closed-Loop Insulin Delivery: A Randomized Crossover Study.
- Authors
Lee, Melissa H.; Vogrin, Sara; Paldus, Barbora; Jayawardene, Dilshani; Jones, Hannah M.; McAuley, Sybil A.; Obeyesekere, Varuni; Gooley, Judith; La Gerche, André; MacIsaac, Richard J.; Sundararajan, Vijaya; Jenkins, Alicia J.; Ward, Glenn M.; O'Neal, David N.
- Abstract
<bold>Objective: </bold>To evaluate exercise-related glucose and counterregulatory responses (CRR) in adults with type 1 diabetes with impaired awareness of hypoglycemia (IAH) using hybrid closed-loop (HCL) insulin delivery to maintain glucose homeostasis.<bold>Research Design and Methods: </bold>Twelve participants undertook 45-min high-intensity intermittent exercise (HIIE) and moderate-intensity exercise (MIE) in random order. The primary outcome was continuous glucose monitoring (CGM) time in range (70-180 mg/dL) for 24-h post-exercise commencement.<bold>Results: </bold>CGM time in range was similar for HIIE and MIE (median 79.5% [interquartile range 73.2, 87.6] vs. 76.1% [70.3, 83.9], P = 0.37), and time with levels <54mg/dL post-exercise commencement was 0%. HIIE induced greater increases in cortisol (P = 0.002), noradrenaline (P = 0.005), and lactate (P = 0.002), with no differences in adrenaline, dopamine, growth hormone, or glucagon responses.<bold>Conclusions: </bold>IAH adults using HCL undertaking HIIE and MIE exhibit heterogeneity in CRR. Novel findings were a preserved cortisol response and variable catecholamine responses to HIIE.
- Subjects
MIE-ken (Japan); TYPE 1 diabetes; HIGH-intensity interval training; HYPOGLYCEMIA; GLUCOSE; INSULIN; BLOOD sugar monitors; BLOOD sugar analysis; RESEARCH; BLOOD sugar monitoring; RESEARCH methodology; COGNITION; BLOOD sugar; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; INSULIN pumps; EXERCISE; CROSSOVER trials; PSYCHOTHERAPY; LACTIC acid
- Publication
Diabetes Care, 2020, Vol 43, Issue 2, p480
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc19-1433