We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Attenuation of contact hypersensitivity by cell-permeable heat shock protein 70 in BALB/c mouse model.
- Authors
Park, Jin Mo; Je, Jeong Hwan; Wu, Wen Hao; Jee, Hyun Joong; Lee, Sang-Kyou; Lee, Min-Geol
- Abstract
In contact hypersensitivity ( CHS), multiple cells, inflammatory mediators and cytokines are known to be involved in the regulation of the immune response. Previously, we revealed the reactive oxygen species generation by 2, 4, 6-trinitrobenzene sulphonic acid ( TNBS) in vivo, followed by heat shock protein 70 (Hsp70) carbonylation and the exogenous antioxidant role of cell-permeable Hsp70. Here, we demonstrate the role of Hsp70 using cell-permeable Hsp70 in the mouse CHS model. Pretreatment of cell-permeable Hsp70: (i) suppressed ear swelling; (ii) down-regulated phosphorylated p38, but up-regulated phosphorylated extracellular signal-regulated kinase; (iii) increased population of CD4+ CD25+Foxp3+ T cells; (iv) decreased secretion of tumor necrosis factor-α ( TNF-α), IL-12, interferon-γ and IL-2 and (v) but up-regulated IL-4 and transforming growth factor beta ( TGF-β) in the lymph nodes. In conclusion, cell-permeable Hsp70 attenuates CHS through modulation of MAPK pathway and regulation of Th1, Th2 and regulatory T cells.
- Subjects
LETTERS to the editor; CONTACT dermatitis; HEAT shock proteins
- Publication
Experimental Dermatology, 2012, Vol 21, Issue 12, p969
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12044