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- Title
Life-span carcinogenicity studies on Sprague-Dawley rats exposed to γ-radiation: Design of the project and report on the tumor occurrence after post-natal radiation exposure (6 weeks of age) delivered in a single acute exposure.
- Authors
Soffritti, Morando; Tibaldi, Eva; Bua, Luciano; Padovani, Michela; Falcioni, Laura; Lauriola, Michelina; Manservigi, Marco; Manservisi, Fabiana; Belpoggi, Fiorella
- Abstract
Background Experimental long-term carcinogenicity bioassays conducted on rats and mice proved that ionizing radiation can induce a variety of tumor types. However few studies have been conducted on rats. Methods This report deals with the effects of γ-radiation in groups of 416-1,051 6-weeks old Sprague-Dawley rats exposed to 0, 0.1, 1, or 3 Gy of γ-radiation delivered in a single acute exposure. The experiment lasted for the animals' lifespan and all were necropsied and underwent full histopathological evaluation. Results The results confirm the dose-related carcinogenic effects of γ-radiation for several organs and tissues. Moreover they indicate that exposure to 0.1 Gy induces a statistically significant increased incidence in Zymbal gland carcinomas and pancreas islet cell carcinomas in females. Conclusions Our data show that exposure to γ-radiation induces carcinogenic effects at all tested doses. Am. J. Ind. Med. 58:46-60, 2015. © 2014 Wiley Periodicals, Inc.
- Subjects
PANCREATIC cancer; CARCINOGENICITY; LABORATORY mice; RADIATION; HISTOPATHOLOGY
- Publication
American Journal of Industrial Medicine, 2015, Vol 58, Issue 1, p46
- ISSN
0271-3586
- Publication type
Article
- DOI
10.1002/ajim.22391