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- Title
Complete genome sequence of Treponema pallidum strain DAL-1.
- Authors
Zobaníková, Marie; Mikolka, Pavol; Čejková, Darina; PospíŠilová, Petra; Lei Chen; Strouhal, Michal; Xiang Qin; Weinstock, George M.; Šmajs, David
- Abstract
Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
- Subjects
TREPONEMA pallidum; NUCLEOTIDE sequence; SYPHILIS; AMNIOTIC liquid; PREGNANT women; RABBITS; ANIMAL models in research
- Publication
Standards in Genomic Sciences, 2012, Vol 7, Issue 1, p12
- ISSN
1944-3277
- Publication type
Article
- DOI
10.4056/sigs.2615838