We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluating the Thyroid Function in Pediatric Nephrotic Syndrome: A study conducted in Ahvaz, Iran.
- Authors
Ebadi, Ameneh; Yadollahpour, Ali; Shirali, Saeed; Daneghian, Sevana; Saki, Sara
- Abstract
Nephrotic syndrome is a nonspecific kidney disorder, characterized by a number of signs of disease including proteinuria, hypoalbuminemia and edema and also an increase in permeability of the capillary walls of the glomerulus leading to the presence of high levels of protein passing from the blood into the urine. Nephrotic syndrome causes lose of plasma proteins and macromolecules leading to their deficiencies and heavy proteinuria. Nephrotic syndrome patients show different thyroid hormone profile although total T4 and T3 may be low due to urine loss of thyroxine-binding globulin. This was a clinical trial study conducted on 20 children with Nephrotic syndrome. The serum T3, T4 and TSH levels of the patients were measured with ELIZA method and then compared with the data of 20 healthy children who were matched by age, gender and other main demographic data to the patients. The T4 and T3 levels in nephrotic syndrome patients were low and TSH levels were high showing a hypothyroidism profile. However, the T4 levels were significantly low in Nephrotic syndrome compared to the healthy group. Due to proteinuria because of nephrotic syndrome and lose of TBG and albumin (the proteins that thyroid hormones bind to) the levels of T3 and T4 in the blood were low and of TSH were high showing a hypothyroidism profile in nephrotic syndrome children.
- Subjects
THYROID hormones; NEPHROTIC syndrome in children; PROTEINURIA; EDEMA; BLOOD proteins; URINALYSIS; CLINICAL trials
- Publication
International Journal of Pharmaceutical Research & Allied Sciences, 2016, Vol 5, Issue 2, p82
- ISSN
2277-3657
- Publication type
Article