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- Title
Preparation and Evaluation of Famotidine Containing Chewing Gum.
- Authors
Mehmood, Yasir; Bashir, Irfan; Majeed, Imtiaz; Alvi, Nadeem; Jamshaid, Muhammad; Khan, Khalid Idrees; Jamshaid, Usama
- Abstract
Most of the drugs are used by oral route. This is most convenient for the patient. Some time it is difficult for the children to take medicine by conventional form like tablets, syrup. Chewing gum form is most attractive form of dosage which can take by oral route and all, the people specially like to chew this type of dosage form. This system is convenient, easy to administer for anyone with pleasant taste. This is one of the novel drug delivery system containing different ingredients and this is very suitable for the drug which has great absorption in the buccal cavity. and this dosage form can be used for the local treatment of the buccal cavity. Chewing gum is the convenient and effective means of rapidly administering fomotidine, as it is readily soluble, permeable and used to relieve symptoms of acidity. In this study medicated chewing gum of famotidine has been developed by using of sorbitol, maganesium sterate, menthol, gum base and sugar. This chewing gum was formulated by the direct compression method. There are different concentrations of base gum and PEG 6000 used. In this formulation PEG 6000 is used as a plasticizer and gives great release profile of the drug.
- Subjects
FAMOTIDINE; CHEWING gum; ORAL drug administration; PLASTICIZERS; SORBITOL
- Publication
International Journal of Pharmaceutical Research & Allied Sciences, 2014, Vol 3, Issue 4, p78
- ISSN
2277-3657
- Publication type
Article