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- Title
A patient with plaque-stage mycosis fungoides has successfully been treated with long-term administration of IFN -- γ and has been in complete remission for more than 6 years.
- Authors
Horikoshi, T.; Onodera, H.; Eguchi, H.; Hanada, N.; Fukuzawa, K.; Takahashi, M.; Ishihara, K.; Ikeda, S.
- Abstract
We report the successful treatment of a patient with plaque-stage mycosis fungoides with long-term and intravenous administration of recombinant human interferon-γ (IFN-γ) and discuss the possible mechanisms of this therapy. A 55-year-old female patient had been resistant to existing treatments and had suffered repeated exacerbations over a 5-year period. Four weeks after initiation of 2 × 106 U/day of IFN-γ, a >10% decrease in the affected surface area was noted. Twenty-two weeks after the administration of 228 × 106 U of IFN-γ, complete remission (CR) was obtained. The CR continued for 13 weeks, but this was followed by an exacerbation. The second CR was obtained after the IFN-γ dosage was increased to 16 × 106/week. The dosage was then gradually reduced by 2–4 × 106 U every 2 or 3 months. She was treated with a total dose of 2814 × 106 of IFN-γ. She has been followed up for more than 6 years, and there has been no recurrence of mycotic skin lesions nor any visceral involvement. During therapy, no serious side-effects were noted. Long-term administration of IFN-γ is useful for the treatment of patients with intractable mycosis fungoides. A gradual decrease in the dose of IFN-γ is important for maintaining remission.
- Subjects
MYCOSES; INTERFERONS; SKIN diseases; DERMATOLOGY; CLINICAL trials
- Publication
British Journal of Dermatology, 1996, Vol 134, Issue 1, p130
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1996.tb07852.x