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- Title
Cu(OAc)<sub>2</sub>·H<sub>2</sub>O/NH<sub>2</sub>OH·HCl/CH<sub>3</sub>COONa: A Facile and Efficient Catalyst System for Copper‐catalyzed Azide–Alkyne Click Reactions in Water.
- Authors
Jiang, Yu‐Qin; Wu, Kai; Fan, Li‐Ming; Zhao, Jing‐Lin; Yang, Yu‐Qing; Zhang, Wei‐Wei; Xu, Gui‐Qing
- Abstract
A facile and efficient protocol has been developed for synthesis of 1,4‐disubstituted 1,2,3‐triazoles in good to excellent yields using Cu(OAc)2·H2O (0.5 mol%)/NH2OH·HCl (0.5 mol%)/CH3COONa (1.0 mol%) as the catalyst system. The presence of CH3COONa (2 equiv) could ensure the in situ generation of Cu2O as the active catalyst instead of CuCl from Cu(OAc)2·H2O (1 equiv)/NH2OH·HCl (1 equiv). This protocol could be carried out in water under mild conditions.
- Subjects
TRIAZOLES synthesis; WATER analysis; CHEMICAL reactions; RING formation (Chemistry); COPPER azides
- Publication
Journal of the Chinese Chemical Society, 2018, Vol 65, Issue 5, p505
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201700339