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- Title
Failure of adefovir 20 mg to improve suboptimal response in lamivudine-resistant hepatitis B patients treated with adefovir 10 mg and lamivudine.
- Authors
Viganò, M.; Lampertico, P.; Facchetti, F.; Lunghi, G.; Colombo, M.
- Abstract
Nine patients with lamivudine-resistant chronic hepatitis B infection who had been treated with adefovir 10 mg/day and had had a suboptimal response but did not have genotypic resistance to adefovir were treated with high-dose adefovir (20 mg/day). The response to the increased dose of adefovir was compared with the response in 15 patients with a suboptimal response who did not receive an increase in the dose of adefovir. The increase in the dose of adefovir did not lead to a significant reduction in hepatitis B DNA when compared with patients maintained on the standard dose. These data suggest that increasing the dose of adefovir in patients with a suboptimal response does not lead to an improved response.
- Subjects
DRUG metabolism; HEPATITIS B; VIRAL hepatitis; INFECTION; DNA; PATIENTS; THERAPEUTICS
- Publication
Journal of Viral Hepatitis, 2008, Vol 15, Issue 12, p922
- ISSN
1352-0504
- Publication type
Article
- DOI
10.1111/j.1365-2893.2008.01047.x