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- Title
Clinicopathological differences between hepatitis B viral genotype B- and C-related resectable hepatocellular carcinoma.
- Authors
Lin, C.-L.; Chen, J.-D.; Liu, C.-J.; Lee, P.-H.; Chen, P.-J.; Lai, M.-Y.; Kao, J.-H.; Chen, D.-S.
- Abstract
Clinical and pathogenic differences exist between hepatitis B viral (HBV) genotypes B and C, and genotype C has a higher risk of hepatocellular carcinoma (HCC) development than genotype B. The aim of this study was to investigate whether HBV genotypes B and C influence the clinicopathological features of patients with resectable HCC. Stored serum samples from 193 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method. Of 193 patients undergoing resection of HCC, 107 (55%) and 86 (45%) were infected with genotypes B and C, respectively. Compared with genotype C patients, genotype B patients were less likely to be associated with liver cirrhosis (33% vs 51%, P = 0.01). Pathologically, genotype B patients had a higher rate of solitary tumour (94% vs 86%, P = 0.048) and more satellite nodules (22% vs 12%, P = 0.05) than genotype C patients. Our results indicate that genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of solitary tumour as well as more satellite nodules than genotype C-related HCC. These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection.
- Subjects
GENETIC polymorphisms; LIVER diseases; VIRAL hepatitis; SURGICAL excision; BLOOD plasma; TUMORS
- Publication
Journal of Viral Hepatitis, 2007, Vol 14, Issue 1, p64
- ISSN
1352-0504
- Publication type
Article
- DOI
10.1111/j.1365-2893.2006.00776.x