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- Title
Bottlenecks in the Investigation of Retinal Sterol Homeostasis.
- Authors
Ramachandra Rao, Sriganesh; Fliesler, Steven J.
- Abstract
Sterol homeostasis in mammalian cells and tissues involves balancing three fundamental processes: de novo sterol biosynthesis; sterol import (e.g., from blood-borne lipoproteins); and sterol export. In complex tissues, composed of multiple different cell types (such as the retina), import and export also may involve intratissue, intercellular sterol exchange. Disruption of any of these processes can result in pathologies that impact the normal structure and function of the retina. Here, we provide a brief overview of what is known currently about sterol homeostasis in the vertebrate retina and offer a proposed path for future experimental work to further our understanding of these processes, with relevance to the development of novel therapeutic interventions for human diseases involving defective sterol homeostasis.
- Subjects
HOMEOSTASIS; RETINA; PHYTOSTEROLS; LIPOPROTEINS; RETINAL degeneration
- Publication
Biomolecules (2218-273X), 2024, Vol 14, Issue 3, p341
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom14030341