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- Title
Beta-herpesviruses in febrile children with cancer.
- Authors
Yee-Guardino S; Gowans K; Yen-Lieberman B; Berk P; Kohn D; Wang FZ; Danziger-Isakov L; Sabella C; Worley S; Pellett PE; Goldfarb J; Yee-Guardino, Stephanie; Gowans, Kate; Yen-Lieberman, Belinda; Berk, Pamela; Kohn, Debra; Wang, Fu-Zhang; Danziger-Isakov, Lara; Sabella, Camille; Worley, Sarah
- Abstract
We conducted a cross-sectional study of beta-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B-positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B-positive children had mild "viral" illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer.
- Publication
Emerging Infectious Diseases, 2008, Vol 14, Issue 4, p579
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid1404.070651