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- Title
Virulence Factors for Hemolytic Uremic Syndrome, Denmark.
- Authors
Ethelberg, Steen; Olsen, Katharina E. P.; Scheutz, Flemming; Jensen, Charlotte; Schiellerup, Peter; Engberg, Jørgen; Petersen, Andreas Munk; Olesen, Bente; Gerner-Smidt, Peter; Mølbak, Kåre
- Abstract
We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.
- Subjects
DENMARK; HEMOLYTIC-uremic syndrome; ESCHERICHIA coli; MICROBIAL virulence; EPIDEMIOLOGY
- Publication
Emerging Infectious Diseases, 2004, Vol 10, Issue 5, p842
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1005.030576