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- Title
Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates.
- Authors
Engberg, Jorgen; Gerner-Smidt, Peter; Aarestrup, Frank M.; Taylor, Diane E.; Nachamkin, Irving; Engberg, J; Aarestrup, F M; Taylor, D E; Gerner-Smidt, P; Nachamkin, I
- Abstract
The incidence of human Campylobacter jejuni and C. coli infections has increased markedly in many parts of the world in the last decade as has the number of quinolone-resistant and, to a lesser extent, macrolide-resistant Campylobacter strains causing infections. We review macrolide and quinolone resistance in Campylobacter and track resistance trends in human clinical isolates in relation to use of these agents in food animals. Susceptibility data suggest that erythromycin and other macrolides should remain the drugs of choice in most regions, with systematic surveillance and control measures maintained, but fluoroquinolones may now be of limited use in the empiric treatment of Campylobacter infections in many regions.
- Subjects
UNITED States; DRUG resistance in microorganisms; CAMPYLOBACTER; QUINOLONE antibacterial agents; ANIMAL diseases; INFECTIOUS disease transmission; ANIMAL experimentation; ANTI-infective agents; ANTIBIOTICS; COMPARATIVE studies; DRUG resistance; MACROLIDE antibiotics; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TIME; EVALUATION research; PHARMACODYNAMICS
- Publication
Emerging Infectious Diseases, 2001, Vol 7, Issue 1, p24
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid0701.010104